COMPLIMENTARY SAMPLES AND FREE CONTINENTAL US SHIPPING ON ALL ORDERS

Your Cart

COMPLEMENTARY SAMPLES AND FREE CONTINENTAL US SHIPPING ON ALL ORDERS

You cart is empty.

Shop Now
||item.title||

||item.title||

    ||item.variants||

||item.price||

Remove
Ingredient Library

RetinO₂™

INCI Names: Retinol; Bakuchiol; Saccharomyces Lysate Extract

Stabilized Retinol + Bakuchiol + Oxygen-Supporting Bioferment

Luzern’s advanced nighttime renewal complex combines stabilized retinol, bakuchiol, and an oxygen-supporting bioferment to visibly smooth lines, refine texture, and support firmer, more radiant-looking skin.

Advanced Retinol Complex / Skin Renewal
Update Category
Best For
Fine Lines & Wrinkles, Uneven Texture, Loss of Firmness, Dullness
Skin Types
All Skin Types Seeking Advanced Age-Defying Care
Naturally Derived?
Partially — combines stabilized retinol with naturally derived bakuchiol and a fermentation-derived yeast bioferment.

Why This Complex Matters

Retinol is one of skincare’s most established ingredients for improving the visible signs of aging—but the quality of a retinol formula depends on much more than simply adding retinol.

RetinO₂™ takes a multi-active approach, combining stabilized retinol with bakuchiol and an oxygen-supporting yeast bioferment. Each plays a complementary role, creating a more complete approach to visible lines, uneven texture, loss of firmness, and dullness.

Rather than using bakuchiol instead of retinol, Luzern brings the two together within an advanced nighttime renewal system.

Why Formulation Matters

More retinol isn’t necessarily better retinol.

Its stability, supporting actives, and overall formulation environment all influence how retinol performs within a skincare formula.

RetinO₂™ begins with stabilized retinol and pairs it with bakuchiol—a complementary age-defying active selected to work alongside the retinol system—and an oxygen-supporting yeast bioferment that helps support a fresh, revitalized-looking complexion.

The oxygen-supporting bioferment is also a foundational technology within Luzern’s Oxygen MFC™ Multi-Fermentation Complex. In RetinO₂™, it becomes part of a targeted nighttime renewal system built around retinol and bakuchiol.

It’s an example of how Luzern uses the same advanced technology differently depending on the purpose of the finished formulation.

Formulation Changes Everything.

How Luzern Uses It

RetinO₂™ is the signature renewal technology in Crème Nuit, Luzern’s advanced overnight moisturizer.


Rather than building the formula around retinol alone, Luzern combines stabilized retinol, bakuchiol, and an oxygen-supporting bioferment to target the appearance of lines, uneven texture, loss of firmness, and dullness.


Crème Nuit further supports this renewal system with Oxygen MFC™, Luzern’s Multi-Fermentation Complex, which brings additional hydration and antioxidant support to help maintain a smoother, fresher, more radiant appearance overnight.


RetinO₂™ remains the primary renewal technology at the heart of Crème Nuit, while Oxygen MFC™ provides complementary hydration, antioxidant defense, and visible vitality.

Found In Luzern Formulations